[Oradlist] bisphosphonate-related osteonecrosis of the jaws

[Rand Redfern]

I am in private practice. I treat only "TMD" patients and use the training I
have in OMR for this daily.

I have many patients with what is suspected to be BIOSNJ. I have the cases
with intraoral lesions, but I also have many cases where it appears that the
condyles and sometimes fossae are involved. These cases are with orals! I
have CBCT and MRI on most of these patients. 

If anyone else is seeing this type of degeneration please let me know.
Studies are forthcoming.

RLRedfern DDS

 

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From: oradlist-bounces at lists.ucla.edu
[mailto:oradlist-bounces at lists.ucla.edu] On Behalf Of Akira Taguchi
Sent: Thursday, October 23, 2008 5:18 AM
To: oradlist at lists.ucla.edu
Subject: [Oradlist] bisphosphonate-related osteonecrosis of the jaws

 

Dear oradlist members,

I would like to ask you about the incidence of bisphosphonate-related
osteonecrosis of the jaw in your University or Institution.
Recently, Japanese dentists are nervous about this problem in comparison to
medical doctors.
Of course, intravenous bisphosphonate may be crucial problem in general
dental practice.  However, it is questionable for patients who have oral
bisphosphonate for osteoporosis or other metabolic disease such as Paget's
disease.

Please let me know about how many patients with oral bis-related and
intravenous bis-related  osteonecrosis of the jaw  you have last 1 year.
Also it is preferable for me if you take specific radiographic finding of
this lesion.

Recently investigators in Horizon study have applied intravenous
bisphosphonate for osteoporosis treatment. They performed RCT (about 3700
case and 3700 control); however, they found each 1 osteonecrosis case for
both case and control during 3 years follow-up. (Post-hoc analysis in the
study of N Engl J Med, 2007; personal communication).

Thank you so much for your information.

Best wishes,

Akira Taguchi

PS. Please send your information to my e-mail address in addition to
oradlist.

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Akira Taguchi, DDS, PhD
Chair and Professor
Department of Oral and Maxillofacial Radiology
Professor
Graduate School of Oral Medicine
Matsumoto Dental University
1780 Gobara, Hirooka, Shiojiri 399-0781 JAPAN
TEL: 81263512095
FAX: 81263512096
E-mail: akiratag at nifty.com
            akiro at po.mdu.ac.jp
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