Low-dose radiation effects

[Koenig, Lisa]

Axel and Julian,  I just read a review of the paper and as I unerstand
it the body takes a risk versus benefit approach to repair.  When the
radiation dose is low and only a few dbs occur the risk of problems
occuring with repair outweigh the risk of ignoring the cells.  When
radiation dose is high and damage is significant the body is forced into
high-gear repair mode.
Lisa

Lisa J Koenig BChD, DDS, MS
Program Director, Oral Medicine and Oral Radiology
Marquette University School of Dentistry
PO Box 1881
Milwaukee, WI 53201-1881
Phone: (414) 288-5675
Fax: (414) 288 6081

-----Original Message-----
From: Axel Ruprecht [mailto:ruprecht at BLUE.WEEG.UIOWA.EDU]
Sent: Tuesday, June 17, 2003 3:37 PM
To: ORADLIST at listserv.ucla.edu
Subject: Re: Low-dose radiation effects


Dr. Julian Gibbs
OM Radiologist

Dear Julian

This paper was basically saying that the double strand repair delay
could be used as a method to show exposure to low doses. It did not come
out and say that this was related to carcinogenesis. of course, it did
not deny it either. So where do you think that this leaves us?

Rgds
Axel



>The paper Axel mentioned in his note today is by Rothkamm and Loebrich,

>in PNAS 200:5057, April 29, 2003.  It follows a related paper by Bonner

>on page 4973.  These papers present the best evidence yet in support of

>low-dose radiation effects. Epidemiologic data show an association
>between human cancer and radiation down to doses of about 100 mSv.  The

>paper cited shows unrepaired double-strand DNA breaks down to 1 mSv.
>These papers have been widely cited.
>Julian
>
>***********************************************************
>S. Julian Gibbs, DDS, PhD              Office: 615-322-1477
>Professor, Emeritus
>Dept. of Radiology & Radiological Sciences
>Vanderbilt University Medical Center     Home: 615-356-3615
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>***********************************************************
>Health nuts are going to feel pretty stupid someday, lying
>in hospitals dying of nothing.
>                              --Anonymous

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Axel Ruprecht D.D.S., M.Sc.D., F.R.C.D.(C)
Professor and Director of Oral and Maxillofacial Radiology Professor of
Radiology Professor of Anatomy and Cell Biology

   (O) 319-335-7341
   (FAX) 319-335-7351

   e-mail:axel-ruprecht at uiowa.edu

   mail: University of Iowa - DSB
            Iowa City  IA 52242-1001

Web: http://ruprecht.radiology.uiowa.edu

The only man who ever got all his work
done by Friday was Robinson Crusoe.

"Education is what remains after one has forgotten what
one has learned in school."    -- Albert Einstein

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