[Bioinformatics] Computational Biosciences Institute Seminar: Dr. Yi Xing, Tuesday, January 10, 2012 @ 10:00am
Bioinformatics IDP-Seminar Series
bioinformatics at lists.ucla.edu
Thu Jan 5 18:31:20 PST 2012
> COMPUTATIONAL BIOSCIENCES INSTITUTE
> YI XING, Ph.D.
> Department of Internal Medicine
> University of Iowa
> “Global insight into post-transcriptional regulation and evolution”
> The long-term goal of my research is to elucidate the regulation of post-transcriptional RNA processing and understand how genomic and environmental variation of post-transcriptional networks impacts cellular functions, phenotypic traits, and diseases. Post-transcriptional regulatory processes, including alternative splicing and alternative polyadenylation, generate enormous functional and regulatory complexity in higher eukaryotes. We have developed computational and statistical tools for global analysis of post-transcriptional regulation using high-throughput sequencing technologies. Through the use of integrated genomic, computational, and molecular approaches we are investigating the variation and dynamics of alternative splicing and post-transcriptional regulatory networks between species, within human populations, and in response to cellular and environmental signals. In this talk, I will discuss two projects in which we study post-transcriptional gene regulation in development and evolution. In the first project, we have combined multiple sequencing technologies (RNA-Seq, DRS, SELEX-Seq) to delineate the complete spectrum of a cell-type-specific post-transcriptional regulatory network during the epithelial-to-mesenchymal transition, which plays a critical role in epithelial cell development and cancer metastasis. In the second project, we are combining high-throughput technologies with computational and molecular studies to systematically survey the evolution of pre-mRNA splicing in primates. By comparing transcriptome profiles across multiple species, we demonstrate that humans and closely related nonhuman primates display widespread differences in exon usage and splicing patterns. Our findings shed light on how evolution of RNA processing shapes the functional and regulatory repertoire of mammalian genomes.
> Tuesday, January 10, 2012
> 10:00 AM
> 2320 Life Sciences Building
> Grace Angus
> UCLA Life Sciences South Administration
> 621 Charles E. Young Drive South
> 2311 Life Sciences Building
> Los Angeles, CA 90095-1606
> (310) 825-4373 (phone)
> (310) 206-0484 (fax)
> gracea at lifesci.ucla.edu
> P Please consider the environment before printing this e-mail.
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