[Bioinformatics] Today's Bioinformatics Seminar: Kevin Thornton, Ph.D.
Bioinformatics IDP-Seminar Series
bioinformatics at lists.ucla.edu
Mon Oct 11 09:12:47 PDT 2010
"Lessons from Population-based
Resequencing in Drosophila"
Kevin Thornton, Ph.D.
Department of Ecology and Evolutionary Biology, UCI
TODAY: October 11, 2010
I will describe two applications of high-throughput sequencing to evolutionary studies in Drosophila. The first application is the sequencing of pooled samples of laboratory populations that have been selected for rapid development time. Pooled samples are a low-cost way of estimating allele frequencies genome-wide, at the cost of losing haplotype information. The study reveals several of the challenges of experimental evolution in eukaryotic systems, while also demonstrating the feasibility and accuracy of pooled samples for evolutionary studies. The second project is an ongoing study of copy-number variation (CNVs) in the Drosophila genus. We are currently sequencing wild-type, isofemale lines from several species to very high depth. The informatics challenges related to the study of CNVs will be discussed.
Host: Matteo Pellegrini, x50012
Refreshments will be served after the seminar
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